Estrogens in intrahepatic cholestasis of pregnancy
Identifieur interne : 009E99 ( Main/Exploration ); précédent : 009E98; suivant : 009F00Estrogens in intrahepatic cholestasis of pregnancy
Auteurs : Kimberly K. Leslie [États-Unis] ; Leonid Reznikov [États-Unis] ; Francis R. Simon [États-Unis] ; Paul V. Fennessey [États-Unis] ; Humberto Reyes [Chili] ; Jose Ribalta [Chili]Source :
- Obstetrics & Gynecology [ 0029-7844 ] ; 2000.
English descriptors
- Teeft :
- American college, Bile acids, Chile, Cholestasis, Cord blood, Dhea, Dhea sulfate, Estrogen, Fetal, Glucuronidated, Gynecology, Intrahepatic, Intrahepatic cholestasis, Null hypothesis, Obstet, Obstet gynecol, Obstetrics, Obstetrics gynecology, Pregnancy, Progesterone, Steroid, Sulfate, Sulfated, Sulfated fraction, Unconjugated, Urinary, Urine, Urine samples.
Abstract
Abstract: Objective: To determine whether estrogen production and excretion are impaired in gravidas with intrahepatic cholestasis. Methods: Plasma and urine samples were collected from 13 women from the United States and Chile at 35–38 weeks’ gestation with mild (n = 9) or severe (n = 4) intrahepatic cholestasis of pregnancy. Urinary and plasma steroid levels from women with cholestasis were compared with levels from 27 normal pregnant women within the same gestational age range. Urinary concentrations of dehydroepiandrosterone (DHEA), estrone (E1), estradiol (E2), estriol (E3), estetrol, progesterone, and 16-hydroxy-pregnenolone were measured by gas chromatography mass spectrometry, and plasma concentrations of DHEA sulfate, progesterone, unconjugated E1, unconjugated E2, unconjugated E3, sulfated E3 derivatives, glucuronidated E3 derivatives, and total E3 were measured by radioimmunoassay. Results: Compared with normal pregnant women, women with cholestasis had significantly lower plasma levels of estrogens and DHEA sulfate, the precursor to placental estrogen production synthesized by the fetal adrenal gland (Hotelling-Lawley trace = 0.81; F4,19 = 3.9; P = .02). The mean plasma DHEA sulfate, unconjugated E2, unconjugated E3, and total E3 concentrations were 0.271, 10.21, 9.80, and 99.53 ng/mL, respectively, in women with cholestasis compared with 0.802, 18.98, 16.28, and 145.07 ng/mL for controls. Conclusion: Fetal adrenal production of DHEA sulfate, and in response, downstream placental production of estrogens, was compromised by intrahepatic cholestasis of pregnancy.
Url:
DOI: 10.1016/S0029-7844(99)00533-5
Affiliations:
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Leslie</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics and Gynecology, the University of Colorado Health Sciences Center, Denver, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Reznikov, Leonid" sort="Reznikov, Leonid" uniqKey="Reznikov L" first="Leonid" last="Reznikov">Leonid Reznikov</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics and Gynecology, the University of Colorado Health Sciences Center, Denver, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Simon, Francis R" sort="Simon, Francis R" uniqKey="Simon F" first="Francis R" last="Simon">Francis R. Simon</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology of the Department of Medicine, the University of Colorado Health Sciences Center, Denver, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Fennessey, Paul V" sort="Fennessey, Paul V" uniqKey="Fennessey P" first="Paul V" last="Fennessey">Paul V. Fennessey</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gas Chromatography/Mass Spectrometry Core Laboratory of the Department of Pediatrics, the University of Colorado Health Sciences Center, Denver, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Reyes, Humberto" sort="Reyes, Humberto" uniqKey="Reyes H" first="Humberto" last="Reyes">Humberto Reyes</name><affiliation wicri:level="1"><country xml:lang="fr">Chili</country><wicri:regionArea>Departments of Medicine and Experimental Medicine, Eastern Campus, University of Chile School of Medicine, Hospital del Salvador, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Ribalta, Jose" sort="Ribalta, Jose" uniqKey="Ribalta J" first="Jose" last="Ribalta">Jose Ribalta</name><affiliation wicri:level="1"><country xml:lang="fr">Chili</country><wicri:regionArea>Departments of Medicine and Experimental Medicine, Eastern Campus, University of Chile School of Medicine, Hospital del Salvador, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Obstetrics & Gynecology</title><title level="j" type="abbrev">ONG</title><idno type="ISSN">0029-7844</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">95</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="372">372</biblScope><biblScope unit="page" to="376">376</biblScope></imprint><idno type="ISSN">0029-7844</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0029-7844</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>American college</term><term>Bile acids</term><term>Chile</term><term>Cholestasis</term><term>Cord blood</term><term>Dhea</term><term>Dhea sulfate</term><term>Estrogen</term><term>Fetal</term><term>Glucuronidated</term><term>Gynecology</term><term>Intrahepatic</term><term>Intrahepatic cholestasis</term><term>Null hypothesis</term><term>Obstet</term><term>Obstet gynecol</term><term>Obstetrics</term><term>Obstetrics gynecology</term><term>Pregnancy</term><term>Progesterone</term><term>Steroid</term><term>Sulfate</term><term>Sulfated</term><term>Sulfated fraction</term><term>Unconjugated</term><term>Urinary</term><term>Urine</term><term>Urine samples</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Objective: To determine whether estrogen production and excretion are impaired in gravidas with intrahepatic cholestasis. Methods: Plasma and urine samples were collected from 13 women from the United States and Chile at 35–38 weeks’ gestation with mild (n = 9) or severe (n = 4) intrahepatic cholestasis of pregnancy. Urinary and plasma steroid levels from women with cholestasis were compared with levels from 27 normal pregnant women within the same gestational age range. Urinary concentrations of dehydroepiandrosterone (DHEA), estrone (E1), estradiol (E2), estriol (E3), estetrol, progesterone, and 16-hydroxy-pregnenolone were measured by gas chromatography mass spectrometry, and plasma concentrations of DHEA sulfate, progesterone, unconjugated E1, unconjugated E2, unconjugated E3, sulfated E3 derivatives, glucuronidated E3 derivatives, and total E3 were measured by radioimmunoassay. Results: Compared with normal pregnant women, women with cholestasis had significantly lower plasma levels of estrogens and DHEA sulfate, the precursor to placental estrogen production synthesized by the fetal adrenal gland (Hotelling-Lawley trace = 0.81; F4,19 = 3.9; P = .02). The mean plasma DHEA sulfate, unconjugated E2, unconjugated E3, and total E3 concentrations were 0.271, 10.21, 9.80, and 99.53 ng/mL, respectively, in women with cholestasis compared with 0.802, 18.98, 16.28, and 145.07 ng/mL for controls. Conclusion: Fetal adrenal production of DHEA sulfate, and in response, downstream placental production of estrogens, was compromised by intrahepatic cholestasis of pregnancy.</div></front></TEI><affiliations><list><country><li>Chili</li><li>États-Unis</li></country><region><li>Colorado</li></region></list><tree><country name="États-Unis"><region name="Colorado"><name sortKey="Leslie, Kimberly K" sort="Leslie, Kimberly K" uniqKey="Leslie K" first="Kimberly K" last="Leslie">Kimberly K. Leslie</name></region><name sortKey="Fennessey, Paul V" sort="Fennessey, Paul V" uniqKey="Fennessey P" first="Paul V" last="Fennessey">Paul V. Fennessey</name><name sortKey="Reznikov, Leonid" sort="Reznikov, Leonid" uniqKey="Reznikov L" first="Leonid" last="Reznikov">Leonid Reznikov</name><name sortKey="Simon, Francis R" sort="Simon, Francis R" uniqKey="Simon F" first="Francis R" last="Simon">Francis R. Simon</name></country><country name="Chili"><noRegion><name sortKey="Reyes, Humberto" sort="Reyes, Humberto" uniqKey="Reyes H" first="Humberto" last="Reyes">Humberto Reyes</name></noRegion><name sortKey="Ribalta, Jose" sort="Ribalta, Jose" uniqKey="Ribalta J" first="Jose" last="Ribalta">Jose Ribalta</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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